The Leonard Weiler House was constructed in 1865 of cream brick (pressed brick on the façade, common brick on the sides and rear). It is very unusual architecturally because its basic Italianate style is blended with a Greek Revival-influenced pair of balanced side wings with separate entrances which made the first floor townhouse functional. There is also a water table around the base of the building.

The Weiler family came to this area from Wurttemberg during the 1840s and four generations occupied the property for 140 years. The activities of the family were intermeshed with such themes in American history as the religious revival of the 1840s, the building of the plank roads, urbanization, and the emancipation of women. Members of the family have donated to the Greenfield Historical Society hundreds of items (photographs, artifacts, printed materials and manuscripts) which document their activities.

Central Builders and Remodeling, which owned the building in the mid-1990s, went to great lengths to improve the interior of the structure while maintaining its exterior integrity.